Can the misfortune of brain injury shed light on the workings of the normal brain, perhaps even help solve some of the eternal riddles of human nature? Understanding the human brain is one of the ultimate challenges in science. Dr. Vilanyur Ramachandran is revolutionizing our understanding of how the brain works. His efforts to solve some of the most baffling neurological mysteries take him from the hospital bed to the outer limits of brain science. He is fascinated by patients who have unusual abilities or defects in the way they perceive the world. These include such puzzling phenomena as the phantom pain experienced in a missing, amputated limb, or the inability to recognize a familiar face following a stroke. From these strange cases, Ramachandran is building a novel vision of how the brain works. This documentary dramatizes the intimate stories of Ramachandran’s encounters with his extraordinary patients.