Since the beginning of recorded historyinfectious disease has reigned supreme as the number one killer on the planet. As scientists and leaders around the world brace for the next global health disaster, some experts are looking for help in the most unlikely of places the past. From London’s Great Plague of 1665 to the AIDS crisis of today, Secrets of the Great Plague follows medical detective Stephen O’Brien as he unravels the mysteries surrounding our most deadly epidemics. The horrors of the Great Plague or “Black Death” could provide lessons that help save lives in the event of an infectious disease disaster. Scientists probe the mystery of why some people survived the infection that killed millions over the centuries when it struck again and again. They have discovered a trick of nature that outsmarted the vicious killer. The same trickor gene mutation, also provided the descendants of the survivors of the “Black Death” with protection against a modern devastating plagueHIV-AIDS. Medical forensic geneticist Dr. Stephen O’Brien is on the case and explores the occurrence of this mutation, known as Delta 32, in people across three continents. He brings exciting news that, with unpicking and examining this naturally occurring defence mechanism, doctors may be on the brink of finding a way to successfully treat AIDS, SARS, leukaemia, prostate cancer, breast cancer, Alzheimer’s, Parkinson’s and a litany of other diseases.